Assay Detail
Binding
CHEMBL3281104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human thrombin-mediated blood clotting formation in presence of human fibrinogen
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.94 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3277934 | — | — | 1 | 6.14 |
| CHEMBL3277923 | — | — | 1 | 6.00 |
| CHEMBL3277936 | — | — | 1 | 5.40 |
| CHEMBL3277921 | — | — | 1 | 5.19 |
| CHEMBL3277925 | — | — | 1 | 5.10 |
| CHEMBL3277935 | — | — | 1 | 5.00 |
| CHEMBL3277919 | — | — | 1 | 4.89 |
| CHEMBL3277933 | — | — | 1 | 4.82 |
| CHEMBL3277918 | — | — | 1 | 4.77 |
| CHEMBL3277927 | — | — | 1 | 4.70 |
| CHEMBL3277931 | — | — | 1 | 4.70 |
| CHEMBL3277920 | — | — | 1 | 4.60 |
| CHEMBL3277929 | — | — | 1 | 4.52 |
| CHEMBL3277930 | — | — | 1 | 4.14 |
| CHEMBL3277926 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3277934 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3277923 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3277936 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3277921 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3277925 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3277935 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3277919 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3277933 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3277918 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3277927 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3277931 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3277920 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3277929 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3277930 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL3277926 | — | IC50 | = | 80000.0 | nM | 4.10 |