Assay Detail
Binding
CHEMBL3284707
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Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence of CH2-H4-folate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.20 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211312 | DEOXYURIDINE MONOPHOSPHATE | — | 1 | 5.65 |
| CHEMBL3274191 | — | — | 1 | 5.41 |
| CHEMBL394429 | THYMIDINE MONOPHOSPHATE | — | 1 | 5.06 |
| CHEMBL1236538 | — | — | 1 | 5.03 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211312 | DEOXYURIDINE MONOPHOSPHATE | Ki | = | 2260.0 | nM | 5.65 |
| CHEMBL3274191 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL394429 | THYMIDINE MONOPHOSPHATE | Ki | = | 8690.0 | nM | 5.06 |
| CHEMBL1236538 | — | Ki | = | 9390.0 | nM | 5.03 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | Ki | = | 14900.0 | nM | 4.83 |