Assay Detail
Binding
CHEMBL3286058
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Inhibition of [3H]norepinephrine uptake at NET expressed in rat hypothalamic homogenate containing synaptosomes after 5 mins by scintillation counting analysis
5
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.59 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405 | AMPHETAMINE | 4.0 | 1 | 6.70 |
| CHEMBL3278291 | — | — | 4 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405 | AMPHETAMINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3278291 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3278291 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3278291 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3278291 | — | IC50 | = | 18000.0 | nM | 4.75 |