Assay Detail
Binding
CHEMBL3286059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dopamine uptake at dopamine transporter expressed in rat striatal homogenate after 5 mins by scintillation counting analysis
5
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.24 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405 | AMPHETAMINE | 4.0 | 1 | 6.02 |
| CHEMBL3278291 | — | — | 4 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405 | AMPHETAMINE | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3278291 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3278291 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3278291 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3278291 | — | IC50 | = | 20000.0 | nM | 4.70 |