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Assay Detail

CHEMBL3291701

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to TNF-alpha (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tumor necrosis factor (CHEMBL1825)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.
Chen L, Du J, Dai Q, Zhang H, Pang W, Hu J.
Eur J Med Chem (2014) 83 : 294 -306
PubMed 24974349 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 12 7.65 8.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1922178 GANODERIC ACID H 1 8.61
CHEMBL453981 GANODERIC ACID F 1 8.57
CHEMBL255489 1 8.42
CHEMBL1922174 GANODERIC ACID C2 1 8.08
CHEMBL602899 GANODERIC ACID A 1 8.07
CHEMBL1087180 GANODERIC ACID B 1 8.05
CHEMBL3289609 1 7.89
CHEMBL1915761 GANODERIOL F 1 7.78
CHEMBL2205002 GANODERIC ACID D 1 7.73
CHEMBL487017 APIGETRIN 1 6.70
CHEMBL233929 GALUTEOLIN 1 6.10
CHEMBL3289608 1 5.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1922178 GANODERIC ACID H Kd = 2.45 nM 8.61
CHEMBL453981 GANODERIC ACID F Kd = 2.69 nM 8.57
CHEMBL255489 Kd = 3.81 nM 8.42
CHEMBL1922174 GANODERIC ACID C2 Kd = 8.39 nM 8.08
CHEMBL602899 GANODERIC ACID A Kd = 8.53 nM 8.07
CHEMBL1087180 GANODERIC ACID B Kd = 8.81 nM 8.05
CHEMBL3289609 Kd = 12.9 nM 7.89
CHEMBL1915761 GANODERIOL F Kd = 16.8 nM 7.78
CHEMBL2205002 GANODERIC ACID D Kd = 18.6 nM 7.73
CHEMBL487017 APIGETRIN Kd = 200.0 nM 6.70
CHEMBL233929 GALUTEOLIN Kd = 790.0 nM 6.10
CHEMBL3289608 Kd = 1820.0 nM 5.74