Assay Detail
Functional
CHEMBL3291706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of guaiane-type sesquiterpene lactone derivatives with respect to inhibiting NO production in lipopolysaccharide-induced RAW 264.7 macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.77 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289855 | — | — | 1 | 5.16 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 5.06 |
| CHEMBL3289622 | — | — | 1 | 4.83 |
| CHEMBL3289848 | — | — | 1 | 4.76 |
| CHEMBL3289640 | — | — | 1 | 4.74 |
| CHEMBL3289639 | — | — | 1 | 4.65 |
| CHEMBL3289856 | — | — | 1 | 4.59 |
| CHEMBL3289633 | — | — | 1 | 4.57 |
| CHEMBL3289632 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289855 | — | IC50 | = | 6980.0 | nM | 5.16 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL3289622 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL3289848 | — | IC50 | = | 17410.0 | nM | 4.76 |
| CHEMBL3289640 | — | IC50 | = | 18330.0 | nM | 4.74 |
| CHEMBL3289639 | — | IC50 | = | 22340.0 | nM | 4.65 |
| CHEMBL3289856 | — | IC50 | = | 25720.0 | nM | 4.59 |
| CHEMBL3289633 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL3289632 | — | IC50 | = | 28960.0 | nM | 4.54 |