Assay Detail
Binding
CHEMBL3291944
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Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scintillation counting
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.36 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089318 | OPICAPONE | 4.0 | 2 | 9.00 |
| CHEMBL3289430 | — | — | 2 | 5.20 |
| CHEMBL3289432 | — | — | 2 | 5.10 |
| CHEMBL3289431 | — | — | 2 | 4.60 |
| CHEMBL3289429 | — | — | 2 | 3.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089318 | OPICAPONE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1089318 | OPICAPONE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3289430 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL3289432 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL3289432 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL3289430 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL3289431 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL3289431 | — | Ki | = | 25118.86 | nM | 4.60 |
| CHEMBL3289429 | — | Ki | = | 251000.0 | nM | 3.60 |
| CHEMBL3289429 | — | Ki | = | 251188.64 | nM | 3.60 |