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Assay Detail

CHEMBL3291995

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of BuChE (unknown origin) after 5 mins by Ellman's method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL1914)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of α, β-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloid β-induced cytotoxicity.
Bukhari SN, Jantan I, Masand VH, Mahajan DT, Sher M, Naeem-ul-Hassan M, Amjad MW.
Eur J Med Chem (2014) 83 : 355 -365
PubMed 24980117 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 4.52 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL502 DONEPEZIL 4.0 1 5.16
CHEMBL3289926 1 4.91
CHEMBL3289930 1 4.83
CHEMBL3289935 1 4.71
CHEMBL3289936 1 4.64
CHEMBL3289925 1 4.41
CHEMBL3289924 1 4.36
CHEMBL3290191 1 4.25
CHEMBL3289928 1 4.18
CHEMBL3290190 1 4.18
CHEMBL3289929 1 4.05
CHEMBL3289932 1 -
CHEMBL3289933 1 -
CHEMBL3289934 1 -
CHEMBL3289927 1 -
CHEMBL3289937 1 -
CHEMBL3289938 1 -
CHEMBL3289939 1 -
CHEMBL3289940 1 -
CHEMBL3289941 1 -
CHEMBL3289943 1 -
CHEMBL3290187 1 -
CHEMBL3290188 1 -
CHEMBL3290189 1 -
CHEMBL3290192 1 -
CHEMBL3290193 1 -
CHEMBL3290194 1 -
CHEMBL3290195 1 -
CHEMBL3290196 1 -
CHEMBL3289942 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL502 DONEPEZIL IC50 = 6920.0 nM 5.16
CHEMBL3289926 IC50 = 12340.0 nM 4.91
CHEMBL3289930 IC50 = 14660.0 nM 4.83
CHEMBL3289935 IC50 = 19740.0 nM 4.71
CHEMBL3289936 IC50 = 22650.0 nM 4.64
CHEMBL3289925 IC50 = 38530.0 nM 4.41
CHEMBL3289924 IC50 = 43660.0 nM 4.36
CHEMBL3290191 IC50 = 56920.0 nM 4.25
CHEMBL3289928 IC50 = 65270.0 nM 4.18
CHEMBL3290190 IC50 = 66750.0 nM 4.18
CHEMBL3289929 IC50 = 88930.0 nM 4.05
CHEMBL3289931 IC50 > 100000.0 nM -
CHEMBL3289932 IC50 > 100000.0 nM -
CHEMBL3289933 IC50 > 100000.0 nM -
CHEMBL3289934 IC50 > 100000.0 nM -
CHEMBL3289927 IC50 > 100000.0 nM -
CHEMBL3289937 IC50 > 100000.0 nM -
CHEMBL3289938 IC50 > 100000.0 nM -
CHEMBL3289939 IC50 > 100000.0 nM -
CHEMBL3289940 IC50 > 100000.0 nM -
CHEMBL3289941 IC50 > 100000.0 nM -
CHEMBL3289943 IC50 > 100000.0 nM -
CHEMBL3290187 IC50 > 100000.0 nM -
CHEMBL3290188 IC50 > 100000.0 nM -
CHEMBL3290189 IC50 > 100000.0 nM -
CHEMBL3290192 IC50 > 100000.0 nM -
CHEMBL3290193 IC50 > 100000.0 nM -
CHEMBL3290194 IC50 > 100000.0 nM -
CHEMBL3290195 IC50 > 100000.0 nM -
CHEMBL3290196 IC50 > 100000.0 nM -
CHEMBL3289942 IC50 > 100000.0 nM -