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Assay Detail

CHEMBL3292012

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant C-terminal His-tagged SIRT2 (13 to 319 amino acid) after 45 mins by spectrophotometry relative to control
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties.
Yoon YK, Ali MA, Wei AC, Shirazi AN, Parang K, Choon TS.
Eur J Med Chem (2014) 83 : 448 -454
PubMed 24992072 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.39 4.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3290218 1 4.57
CHEMBL595354 1 4.53
CHEMBL491960 CAMBINOL 1 4.34
CHEMBL3290210 1 4.28
CHEMBL3290220 1 4.22
CHEMBL3290211 1 -
CHEMBL3290212 1 -
CHEMBL3290213 1 -
CHEMBL3290214 1 -
CHEMBL3290215 1 -
CHEMBL3290216 1 -
CHEMBL3290217 1 -
CHEMBL3290219 1 -
CHEMBL3290209 1 -
CHEMBL3290222 1 -
CHEMBL3290223 1 -
CHEMBL3290224 1 -
CHEMBL3290221 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3290218 IC50 = 26850.0 nM 4.57
CHEMBL595354 IC50 = 29730.0 nM 4.53
CHEMBL491960 CAMBINOL IC50 = 45860.0 nM 4.34
CHEMBL3290210 IC50 = 52780.0 nM 4.28
CHEMBL3290220 IC50 = 60600.0 nM 4.22
CHEMBL3290211 IC50 - -
CHEMBL3290212 IC50 - -
CHEMBL3290213 IC50 - -
CHEMBL3290214 IC50 - -
CHEMBL3290215 IC50 - -
CHEMBL3290216 IC50 - -
CHEMBL3290217 IC50 - -
CHEMBL3290219 IC50 - -
CHEMBL3290209 IC50 - -
CHEMBL3290222 IC50 - -
CHEMBL3290223 IC50 - -
CHEMBL3290224 IC50 - -
CHEMBL3290221 IC50 - -