Assay Detail
Functional
CHEMBL3292177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced TNF-alpha production
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.59 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290618 | — | — | 1 | 6.15 |
| CHEMBL3290619 | — | — | 1 | 5.95 |
| CHEMBL3290623 | — | — | 1 | 5.91 |
| CHEMBL3290628 | — | — | 1 | 5.89 |
| CHEMBL3290630 | — | — | 1 | 5.88 |
| CHEMBL3290624 | — | — | 1 | 5.86 |
| CHEMBL3290634 | — | — | 1 | 5.67 |
| CHEMBL3290632 | — | — | 1 | 5.62 |
| CHEMBL3290629 | — | — | 1 | 5.57 |
| CHEMBL3290631 | — | — | 1 | 5.54 |
| CHEMBL129857 | AS-602868 | 1.0 | 1 | 5.48 |
| CHEMBL3290622 | — | — | 1 | 5.40 |
| CHEMBL3290626 | — | — | 1 | 5.38 |
| CHEMBL3290621 | — | — | 1 | 5.36 |
| CHEMBL3290627 | — | — | 1 | 5.28 |
| CHEMBL3290625 | — | — | 1 | 5.05 |
| CHEMBL3290633 | — | — | 1 | 5.00 |
| CHEMBL3290620 | — | — | 1 | - |
| CHEMBL3290613 | — | — | 1 | - |
| CHEMBL3290614 | — | — | 1 | - |
| CHEMBL3290615 | — | — | 1 | - |
| CHEMBL3290616 | — | — | 1 | - |
| CHEMBL3290617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290618 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3290619 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL3290623 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL3290628 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL3290630 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3290624 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL3290634 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL3290632 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL3290629 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL3290631 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL129857 | AS-602868 | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL3290622 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL3290626 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL3290621 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL3290627 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL3290625 | — | IC50 | = | 8950.0 | nM | 5.05 |
| CHEMBL3290633 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL3290620 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290613 | — | IC50 | - | — | - | |
| CHEMBL3290614 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290615 | — | IC50 | - | — | - | |
| CHEMBL3290616 | — | IC50 | - | — | - | |
| CHEMBL3290617 | — | IC50 | - | — | - |