Assay Detail
Functional
CHEMBL3292178
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Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.58 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290628 | — | — | 1 | 6.12 |
| CHEMBL3290630 | — | — | 1 | 6.09 |
| CHEMBL3290629 | — | — | 1 | 5.91 |
| CHEMBL3290634 | — | — | 1 | 5.78 |
| CHEMBL3290626 | — | — | 1 | 5.72 |
| CHEMBL3290620 | — | — | 1 | 5.68 |
| CHEMBL3290631 | — | — | 1 | 5.67 |
| CHEMBL3290618 | — | — | 1 | 5.66 |
| CHEMBL3290614 | — | — | 1 | 5.60 |
| CHEMBL3290624 | — | — | 1 | 5.55 |
| CHEMBL3290621 | — | — | 1 | 5.51 |
| CHEMBL3290619 | — | — | 1 | 5.50 |
| CHEMBL3290632 | — | — | 1 | 5.49 |
| CHEMBL3290623 | — | — | 1 | 5.46 |
| CHEMBL129857 | AS-602868 | 1.0 | 1 | 5.36 |
| CHEMBL3290627 | — | — | 1 | 5.29 |
| CHEMBL3290622 | — | — | 1 | 5.28 |
| CHEMBL3290625 | — | — | 1 | 5.16 |
| CHEMBL3290633 | — | — | 1 | 5.12 |
| CHEMBL3290613 | — | — | 1 | - |
| CHEMBL3290615 | — | — | 1 | - |
| CHEMBL3290616 | — | — | 1 | - |
| CHEMBL3290617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290628 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3290630 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3290629 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL3290634 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL3290626 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL3290620 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3290631 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL3290618 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL3290614 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL3290624 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL3290621 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL3290619 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL3290632 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL3290623 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL129857 | AS-602868 | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL3290627 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL3290622 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL3290625 | — | IC50 | = | 6980.0 | nM | 5.16 |
| CHEMBL3290633 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL3290613 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290615 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290616 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290617 | — | IC50 | > | 10000.0 | nM | - |