Assay Detail
Functional
CHEMBL3292527
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Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by fluorescence linked immunosorbant assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 9.93 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3288029 | — | — | 1 | 10.70 |
| CHEMBL3288022 | — | — | 1 | 10.50 |
| CHEMBL3288028 | — | — | 1 | 10.50 |
| CHEMBL3288024 | — | — | 1 | 10.40 |
| CHEMBL3288030 | — | — | 1 | 10.40 |
| CHEMBL3287739 | — | — | 1 | 10.20 |
| CHEMBL3288027 | — | — | 1 | 10.20 |
| CHEMBL3288010 | — | — | 1 | 10.10 |
| CHEMBL3288023 | — | — | 1 | 10.10 |
| CHEMBL3288012 | — | — | 1 | 10.00 |
| CHEMBL3288011 | — | — | 1 | 9.90 |
| CHEMBL3288009 | — | — | 1 | 9.60 |
| CHEMBL3288025 | — | — | 1 | 9.40 |
| CHEMBL3288026 | — | — | 1 | 8.50 |
| CHEMBL3113734 | UK-500001 | 2.0 | 1 | 8.40 |
| CHEMBL570015 | GSK-256066 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3288029 | — | IC50 | = | 0.01995 | nM | 10.70 |
| CHEMBL3288022 | — | IC50 | = | 0.03162 | nM | 10.50 |
| CHEMBL3288028 | — | IC50 | = | 0.03162 | nM | 10.50 |
| CHEMBL3288024 | — | IC50 | = | 0.03981 | nM | 10.40 |
| CHEMBL3288030 | — | IC50 | = | 0.03981 | nM | 10.40 |
| CHEMBL3287739 | — | IC50 | = | 0.0631 | nM | 10.20 |
| CHEMBL3288027 | — | IC50 | = | 0.0631 | nM | 10.20 |
| CHEMBL3288010 | — | IC50 | = | 0.07943 | nM | 10.10 |
| CHEMBL3288023 | — | IC50 | = | 0.07943 | nM | 10.10 |
| CHEMBL3288012 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3288011 | — | IC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL3288009 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL3288025 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL3288026 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL3113734 | UK-500001 | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL570015 | GSK-256066 | IC50 | = | 0.003162 | nM | - |