Compound Detail
CHEMBL3288027
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Cc1cc(C(=O)N[C@H]2CC[C@@H](NC(=O)c3cc(F)cnc3Oc3cccc(-c4ccc(CCCN5C[C@@H](C)N[C@@H](C)C5)cc4)c3)CC2)nn1C
Basic Information
| ChEMBL ID | CHEMBL3288027 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BOLHCUZVJPHIDF-FLSDQSJTSA-N |
2
Targets
2
Activities
1
Assay Types
3
PK Parameters
10
Publications
0
Known Names
Molecular Properties
681.9
MW (Da)
5.81
ALogP
8
HBA
3
HBD
113.4
PSA (Ų)
0.18
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 10.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 10.7 | 10.7 | 0.0 | 1 |
| PBMC CHEMBL613107 | IC50 | 10.2 | 10.2 | 0.1 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 68.0 | mL.min-1.kg-1 | Rattus norvegicus |
| Fu | 0.045 | - | Homo sapiens |
| T1/2 | 7.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 0.01995 | nM | 10.7 | Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintil... | 24785301 |
| PBMC | IC50 | = | 0.0631 | nM | 10.2 | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TN... | 24785301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24785301 | 10.1021/jm5001216 | Rattus norvegicus | 9 |
| 24785301 | 10.1021/jm5001216 | No relevant target | 2 |
| 24785301 | 10.1021/jm5001216 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 24785301 | 10.1021/jm5001216 | PBMC | 1 |
| 24785301 | 10.1021/jm5001216 | Plasma | 1 |
| 24785301 | 10.1021/jm5001216 | Cytochrome P450 3A4 | 1 |
| 24785301 | 10.1021/jm5001216 | Cytochrome P450 2C9 | 1 |
| 24785301 | 10.1021/jm5001216 | Cytochrome P450 2D6 | 1 |
| 24785301 | 10.1021/jm5001216 | Cytochrome P450 1A2 | 1 |
| 24785301 | 10.1021/jm5001216 | Cytochrome P450 2C19 | 1 |
Data from ChEMBL 36 via Core Engine