Assay Detail
Binding
CHEMBL3292801
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Inhibition of human recombinant carbonic anhydrase 1 pretreated for 15 mins by stopped flow CO2 hydrase assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.85 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3291012 | — | — | 1 | 7.39 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.52 |
| CHEMBL3291011 | — | — | 1 | 5.76 |
| CHEMBL3291010 | — | — | 1 | 5.21 |
| CHEMBL3291009 | — | — | 1 | 5.17 |
| CHEMBL3291013 | — | — | 1 | 5.04 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | - |
| CHEMBL3291000 | — | — | 1 | - |
| CHEMBL3291001 | — | — | 1 | - |
| CHEMBL3291002 | — | — | 1 | - |
| CHEMBL3291003 | — | — | 1 | - |
| CHEMBL3291004 | — | — | 1 | - |
| CHEMBL3291005 | — | — | 1 | - |
| CHEMBL3291006 | — | — | 1 | - |
| CHEMBL3291007 | — | — | 1 | - |
| CHEMBL3291008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3291012 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL3291011 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3291010 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL3291009 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3291013 | — | IC50 | = | 9030.0 | nM | 5.04 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291000 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291001 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291002 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291003 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291004 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291005 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291007 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3291008 | — | IC50 | > | 10000.0 | nM | - |