Assay Detail
Binding
CHEMBL3292817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAO-B in rat liver homogenate using [14C]-phenylethylamine as substrate preincubated for 30 mins followed by substrate addition measured after 4 mins by liquid scintillation counting analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.17 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.17 |
| CHEMBL3291021 | — | — | 1 | 5.82 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.10 |
| CHEMBL3291019 | — | — | 1 | 4.99 |
| CHEMBL3291017 | — | — | 1 | 4.91 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 4.82 |
| CHEMBL3291016 | — | — | 1 | 4.71 |
| CHEMBL3291020 | — | — | 1 | 4.46 |
| CHEMBL3291015 | — | — | 1 | 4.40 |
| CHEMBL3291018 | — | — | 1 | 4.30 |
| CHEMBL3291014 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL3291021 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3291019 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL3291017 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3291016 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL3291020 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL3291015 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL3291018 | — | IC50 | = | 50100.0 | nM | 4.30 |
| CHEMBL3291014 | — | IC50 | >= | 100000.0 | nM | - |