Assay Detail
Functional
CHEMBL3292858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus A2/Taiwan/1/64(H2N2) infected in MDCK cells expressing wild type M2 after overnight incubation by fluorescence-based miniplaque assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.22 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3288286 | — | — | 1 | 6.70 |
| CHEMBL3288287 | — | — | 1 | 6.70 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.47 |
| CHEMBL3288284 | — | — | 1 | 6.40 |
| CHEMBL1172027 | — | — | 1 | 6.30 |
| CHEMBL1170792 | — | — | 1 | 6.10 |
| CHEMBL1170181 | — | — | 1 | 6.10 |
| CHEMBL3288283 | — | — | 1 | 5.82 |
| CHEMBL3288285 | — | — | 1 | 5.82 |
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 5.80 |
| CHEMBL1170182 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3288286 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3288287 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL660 | AMANTADINE | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3288284 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1172027 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1170792 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1170181 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3288283 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3288285 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL959 | RIMANTADINE | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1170182 | — | EC50 | < | 240.0 | nM | - |