Assay Detail
Binding
CHEMBL3293000
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Inhibition of Wnt signaling in human HT29 cells assessed as inhibition of beta-catenin-mediated Tcf/Lef transcriptional activity after 24 hrs by dual luciferase reporter gene assay relative to control
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.55 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3288551 | — | — | 1 | 5.21 |
| CHEMBL3288555 | — | — | 1 | 5.01 |
| CHEMBL3288549 | — | — | 1 | 4.98 |
| CHEMBL3288553 | — | — | 1 | 4.96 |
| CHEMBL3288545 | — | — | 1 | 4.84 |
| CHEMBL3288550 | — | — | 1 | 4.79 |
| CHEMBL3288558 | — | — | 1 | 4.75 |
| CHEMBL2312139 | — | — | 1 | 4.73 |
| CHEMBL3288554 | — | — | 1 | 4.71 |
| CHEMBL3288539 | — | — | 1 | 4.65 |
| CHEMBL3288556 | — | — | 1 | 4.64 |
| CHEMBL3288559 | — | — | 1 | 4.62 |
| CHEMBL562310 | — | — | 1 | 4.61 |
| CHEMBL3288540 | — | — | 1 | 4.51 |
| CHEMBL3288547 | — | — | 1 | 4.46 |
| CHEMBL3288543 | — | — | 1 | 4.45 |
| CHEMBL3288557 | — | — | 1 | 4.38 |
| CHEMBL3288541 | — | — | 1 | 4.37 |
| CHEMBL3288538 | — | — | 1 | 4.33 |
| CHEMBL3288552 | — | — | 1 | 4.28 |
| CHEMBL3288542 | — | — | 1 | 4.26 |
| CHEMBL3288544 | — | — | 1 | 4.24 |
| CHEMBL3288548 | — | — | 1 | 4.17 |
| CHEMBL3288535 | — | — | 1 | 4.14 |
| CHEMBL3288546 | — | — | 1 | 4.14 |
| CHEMBL257487 | — | — | 1 | 4.09 |
| CHEMBL3288560 | — | — | 1 | - |
| CHEMBL3288537 | — | — | 1 | - |
| CHEMBL3288536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3288551 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3288555 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3288549 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL3288553 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL3288545 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3288550 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL3288558 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL2312139 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL3288554 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL3288539 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL3288556 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL3288559 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL562310 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL3288540 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL3288547 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL3288543 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL3288557 | — | IC50 | = | 42200.0 | nM | 4.38 |
| CHEMBL3288541 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3288538 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL3288552 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL3288542 | — | IC50 | = | 54300.0 | nM | 4.26 |
| CHEMBL3288544 | — | IC50 | = | 57800.0 | nM | 4.24 |
| CHEMBL3288548 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL3288535 | — | IC50 | = | 72200.0 | nM | 4.14 |
| CHEMBL3288546 | — | IC50 | = | 72200.0 | nM | 4.14 |
| CHEMBL257487 | — | IC50 | = | 81800.0 | nM | 4.09 |
| CHEMBL3288560 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3288537 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3288536 | — | IC50 | > | 100000.0 | nM | - |