Assay Detail
Binding
CHEMBL3293104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.04 | 9.35 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289390 | — | — | 2 | 9.35 |
| CHEMBL1724 | MEPENZOLATE BROMIDE | 4.0 | 2 | 9.17 |
| CHEMBL3289391 | — | — | 2 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289390 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL1724 | MEPENZOLATE BROMIDE | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL3289391 | — | Ki | = | 2.52 | nM | 8.60 |
| CHEMBL3289390 | — | Inhibition | - | % | - | |
| CHEMBL3289391 | — | Inhibition | - | % | - | |
| CHEMBL1724 | MEPENZOLATE BROMIDE | Inhibition | - | % | - |