Assay Detail
Binding
CHEMBL3293105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human M3R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.27 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289390 | — | — | 1 | 8.68 |
| CHEMBL1724 | MEPENZOLATE BROMIDE | 4.0 | 1 | 8.59 |
| CHEMBL3289391 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289390 | — | Ki | = | 2.11 | nM | 8.68 |
| CHEMBL1724 | MEPENZOLATE BROMIDE | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL3289391 | — | Ki | = | 28.0 | nM | 7.55 |