Assay Detail
Binding
CHEMBL3293530
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Inhibition of rat recombinant DNA polymerase beta expressed in Escherichia coli JMpbeta5 cells assessed as incorporation of [3H]dTTP into poly(dA)/oligo(dT)18 DNA-template primer after 60 mins
10
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Polyketides from the cultured lichen mycobiont of a Vietnamese Pyrenula sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.67 | 5.02 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290498 | — | — | 2 | 5.02 |
| CHEMBL3290502 | — | — | 2 | 4.71 |
| CHEMBL566812 | — | — | 1 | 4.51 |
| CHEMBL3290500 | — | — | 1 | 4.42 |
| CHEMBL3290499 | — | — | 1 | - |
| CHEMBL3290501 | — | — | 1 | - |
| CHEMBL3290503 | — | — | 1 | - |
| CHEMBL29711 | APHIDICOLIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290498 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3290502 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL566812 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL3290500 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL3290499 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3290501 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3290503 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL29711 | APHIDICOLIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL3290498 | — | Inhibition | - | % | - | |
| CHEMBL3290502 | — | Inhibition | - | % | - |