Assay Detail
Binding
CHEMBL3293756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Met (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.53 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 9.40 |
| CHEMBL2031893 | — | — | 1 | 9.00 |
| CHEMBL505896 | — | — | 1 | 8.05 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2031893 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL505896 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 21.0 | nM | 7.68 |