Assay Detail
Functional
CHEMBL3294120
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Vasorelaxant activity in Wistar rat endothelium-intact thoracic aortic rings assessed as inhibition of phenylephrine-induced contraction
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and structure-activity relationships of new phthalazinedione derivatives with vasorelaxant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 5.22 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290869 | — | — | 1 | 5.77 |
| CHEMBL3290849 | — | — | 1 | 5.67 |
| CHEMBL3290858 | — | — | 1 | 5.63 |
| CHEMBL3290856 | — | — | 1 | 5.63 |
| CHEMBL3290852 | — | — | 1 | 5.61 |
| CHEMBL3290854 | — | — | 1 | 5.60 |
| CHEMBL3290870 | — | — | 1 | 5.51 |
| CHEMBL3290874 | — | — | 1 | 5.47 |
| CHEMBL3290861 | — | — | 1 | 5.46 |
| CHEMBL3290853 | — | — | 1 | 5.40 |
| CHEMBL3290857 | — | — | 1 | 5.38 |
| CHEMBL3290860 | — | — | 1 | 5.37 |
| CHEMBL3290862 | — | — | 1 | 5.32 |
| CHEMBL3290859 | — | — | 1 | 5.20 |
| CHEMBL3290872 | — | — | 1 | 5.18 |
| CHEMBL3290871 | — | — | 1 | 5.13 |
| CHEMBL3290873 | — | — | 1 | 5.10 |
| CHEMBL3290866 | — | — | 1 | 5.07 |
| CHEMBL3290855 | — | — | 1 | 5.00 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.77 |
| CHEMBL3290868 | — | — | 1 | 4.35 |
| CHEMBL3290865 | — | — | 1 | 4.31 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 4.16 |
| CHEMBL276832 | HYDRALAZINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290869 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3290849 | — | EC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL3290858 | — | EC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL3290856 | — | EC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL3290852 | — | EC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL3290854 | — | EC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL3290870 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3290874 | — | EC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL3290861 | — | EC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL3290853 | — | EC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL3290857 | — | EC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL3290860 | — | EC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL3290862 | — | EC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL3290859 | — | EC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL3290872 | — | EC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL3290871 | — | EC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL3290873 | — | EC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL3290866 | — | EC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL3290855 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL12856 | INAMRINONE | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3290868 | — | EC50 | = | 44680.0 | nM | 4.35 |
| CHEMBL3290865 | — | EC50 | = | 48720.0 | nM | 4.31 |
| CHEMBL12 | DIAZEPAM | EC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL276832 | HYDRALAZINE | EC50 | = | 1180000.0 | nM | - |