Assay Detail
Functional
CHEMBL3294121
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Vasorelaxant activity in Wistar rat endothelium-denuded thoracic aortic rings assessed as inhibition of phenylephrine-induced contraction
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and structure-activity relationships of new phthalazinedione derivatives with vasorelaxant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 4.84 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290856 | — | — | 1 | 5.43 |
| CHEMBL3290849 | — | — | 1 | 5.31 |
| CHEMBL3290854 | — | — | 1 | 5.25 |
| CHEMBL3290874 | — | — | 1 | 5.17 |
| CHEMBL3290860 | — | — | 1 | 5.13 |
| CHEMBL3290869 | — | — | 1 | 5.07 |
| CHEMBL3290858 | — | — | 1 | 4.93 |
| CHEMBL3290861 | — | — | 1 | 4.88 |
| CHEMBL3290859 | — | — | 1 | 4.88 |
| CHEMBL3290857 | — | — | 1 | 4.88 |
| CHEMBL3290852 | — | — | 1 | 4.84 |
| CHEMBL3290870 | — | — | 1 | 4.81 |
| CHEMBL3290855 | — | — | 1 | 4.80 |
| CHEMBL3290862 | — | — | 1 | 4.74 |
| CHEMBL3290873 | — | — | 1 | 4.70 |
| CHEMBL3290853 | — | — | 1 | 4.63 |
| CHEMBL3290872 | — | — | 1 | 4.57 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.55 |
| CHEMBL3290866 | — | — | 1 | 4.52 |
| CHEMBL3290871 | — | — | 1 | 4.49 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 4.11 |
| CHEMBL276832 | HYDRALAZINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290856 | — | EC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL3290849 | — | EC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL3290854 | — | EC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL3290874 | — | EC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL3290860 | — | EC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL3290869 | — | EC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL3290858 | — | EC50 | = | 11710.0 | nM | 4.93 |
| CHEMBL3290861 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3290859 | — | EC50 | = | 13190.0 | nM | 4.88 |
| CHEMBL3290857 | — | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL3290852 | — | EC50 | = | 14560.0 | nM | 4.84 |
| CHEMBL3290870 | — | EC50 | = | 15450.0 | nM | 4.81 |
| CHEMBL3290855 | — | EC50 | = | 15940.0 | nM | 4.80 |
| CHEMBL3290862 | — | EC50 | = | 18230.0 | nM | 4.74 |
| CHEMBL3290873 | — | EC50 | = | 20160.0 | nM | 4.70 |
| CHEMBL3290853 | — | EC50 | = | 23610.0 | nM | 4.63 |
| CHEMBL3290872 | — | EC50 | = | 27160.0 | nM | 4.57 |
| CHEMBL12856 | INAMRINONE | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3290866 | — | EC50 | = | 30180.0 | nM | 4.52 |
| CHEMBL3290871 | — | EC50 | = | 32550.0 | nM | 4.49 |
| CHEMBL12 | DIAZEPAM | EC50 | = | 77200.0 | nM | 4.11 |
| CHEMBL276832 | HYDRALAZINE | EC50 | = | 1320000.0 | nM | - |