Assay Detail
Binding
CHEMBL3294267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His-tagged KSP ATPase motor domain (unknown origin) expressed in bacteria incubated for 30 mins prior to ATP addition measured after 15 mins by luminescence assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 6.53 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289009 | — | — | 1 | 7.46 |
| CHEMBL3288965 | — | — | 1 | 7.37 |
| CHEMBL3288973 | — | — | 1 | 7.35 |
| CHEMBL3289010 | — | — | 1 | 7.30 |
| CHEMBL3289006 | — | — | 1 | 7.30 |
| CHEMBL3289003 | — | — | 1 | 7.29 |
| CHEMBL1802986 | — | — | 1 | 7.28 |
| CHEMBL3288994 | — | — | 1 | 7.17 |
| CHEMBL3288964 | — | — | 1 | 7.07 |
| CHEMBL1802987 | — | — | 1 | 7.02 |
| CHEMBL1803018 | — | — | 1 | 6.92 |
| CHEMBL3288983 | — | — | 1 | 6.80 |
| CHEMBL3289005 | — | — | 1 | 6.72 |
| CHEMBL1173704 | — | — | 1 | 6.68 |
| CHEMBL3288963 | — | — | 1 | 6.57 |
| CHEMBL3289002 | — | — | 1 | 6.54 |
| CHEMBL3288976 | — | — | 1 | 6.48 |
| CHEMBL3288972 | — | — | 1 | 6.41 |
| CHEMBL3289007 | — | — | 1 | 6.37 |
| CHEMBL3288982 | — | — | 1 | 6.37 |
| CHEMBL3288990 | — | — | 1 | 6.36 |
| CHEMBL3288966 | — | — | 1 | 6.26 |
| CHEMBL3288981 | — | — | 1 | 6.09 |
| CHEMBL3289001 | — | — | 1 | 6.09 |
| CHEMBL3289008 | — | — | 1 | 6.04 |
| CHEMBL3288988 | — | — | 1 | 5.92 |
| CHEMBL3288974 | — | — | 1 | 5.70 |
| CHEMBL3288970 | — | — | 1 | 5.50 |
| CHEMBL3288999 | — | — | 1 | 5.44 |
| CHEMBL3288997 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289009 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3288965 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3288973 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3289010 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3289006 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3289003 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1802986 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3288994 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3288964 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1802987 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1803018 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3288983 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3289005 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1173704 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3288963 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3289002 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3288976 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3288972 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3289007 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3288982 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3288990 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3288966 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3288981 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3289001 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3289008 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3288988 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3288974 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3288970 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3288999 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3288997 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3288961 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3288985 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288986 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288987 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288989 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288975 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288991 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288992 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288993 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288979 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288996 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288995 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288998 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288967 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288968 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3289000 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288969 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288971 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3288962 | — | IC50 | > | 6300.0 | nM | - |
| CHEMBL3289004 | — | IC50 | > | 6300.0 | nM | - |