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Assay Detail

CHEMBL3295046

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Functional
Antiproliferative activity against human CRL2351 cells assessed as inhibition of cell proliferation after 5 days by sulforhodamine B assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction.
Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M.
J Med Chem (2014) 57 : 5094 -5111
PubMed 24827861 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.96 5.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3287106 1 5.39
CHEMBL3287108 1 5.36
CHEMBL3287112 1 5.28
CHEMBL3287116 1 5.04
CHEMBL3287119 1 4.99
CHEMBL3287109 1 4.95
CHEMBL254578 1 4.94
CHEMBL3287113 1 4.81
CHEMBL3287110 1 4.78
CHEMBL3287117 1 4.78
CHEMBL3287115 1 4.75
CHEMBL3287114 1 4.75
CHEMBL3287121 1 4.70
CHEMBL3287111 1 -
CHEMBL3287118 1 -
CHEMBL3287120 1 -
CHEMBL3287122 1 -
CHEMBL3287123 1 -
CHEMBL3287124 1 -
CHEMBL3287125 1 -
CHEMBL3287126 1 -
CHEMBL3287127 1 -
CHEMBL3287128 1 -
CHEMBL3287129 1 -
CHEMBL3287130 1 -
CHEMBL3287131 1 -
CHEMBL3287107 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3287106 IC50 = 4100.0 nM 5.39
CHEMBL3287108 IC50 = 4400.0 nM 5.36
CHEMBL3287112 IC50 = 5200.0 nM 5.28
CHEMBL3287116 IC50 = 9100.0 nM 5.04
CHEMBL3287119 IC50 = 10300.0 nM 4.99
CHEMBL3287109 IC50 = 11200.0 nM 4.95
CHEMBL254578 IC50 = 11600.0 nM 4.94
CHEMBL3287113 IC50 = 15400.0 nM 4.81
CHEMBL3287110 IC50 = 16600.0 nM 4.78
CHEMBL3287117 IC50 = 16700.0 nM 4.78
CHEMBL3287115 IC50 = 17700.0 nM 4.75
CHEMBL3287114 IC50 = 17600.0 nM 4.75
CHEMBL3287121 IC50 = 19800.0 nM 4.70
CHEMBL3287111 IC50 > 20000.0 nM -
CHEMBL3287118 IC50 > 20000.0 nM -
CHEMBL3287120 IC50 > 20000.0 nM -
CHEMBL3287122 IC50 > 20000.0 nM -
CHEMBL3287123 IC50 > 20000.0 nM -
CHEMBL3287124 IC50 > 20000.0 nM -
CHEMBL3287125 IC50 > 20000.0 nM -
CHEMBL3287126 IC50 > 20000.0 nM -
CHEMBL3287127 IC50 > 20000.0 nM -
CHEMBL3287128 IC50 > 20000.0 nM -
CHEMBL3287129 IC50 > 20000.0 nM -
CHEMBL3287130 IC50 > 20000.0 nM -
CHEMBL3287131 IC50 > 20000.0 nM -
CHEMBL3287107 IC50 > 20000.0 nM -