Assay Detail
Binding
CHEMBL3295140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.73 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128729 | — | — | 1 | 5.22 |
| CHEMBL3290185 | — | — | 1 | 4.81 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 4.79 |
| CHEMBL2413471 | — | — | 1 | 4.74 |
| CHEMBL3290186 | — | — | 1 | 4.71 |
| CHEMBL2392188 | — | — | 1 | 4.65 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.47 |
| CHEMBL3290439 | — | — | 1 | 4.45 |
| CHEMBL318743 | TETRAHYDROCURCUMIN | — | 1 | - |
| CHEMBL2392187 | — | — | 1 | - |
| CHEMBL2392186 | — | — | 1 | - |
| CHEMBL3290441 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128729 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3290185 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL2413471 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL3290186 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL2392188 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL140 | CURCUMIN | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL3290439 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL318743 | TETRAHYDROCURCUMIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL2392187 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2392186 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3290441 | — | IC50 | > | 50000.0 | nM | - |