Assay Detail
ADMET
CHEMBL3295142
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Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.60 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128729 | — | — | 1 | 5.00 |
| CHEMBL3290186 | — | — | 1 | 4.60 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.44 |
| CHEMBL2392188 | — | — | 1 | 4.36 |
| CHEMBL3290439 | — | — | 1 | - |
| CHEMBL318743 | TETRAHYDROCURCUMIN | — | 1 | - |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | - |
| CHEMBL2413471 | — | — | 1 | - |
| CHEMBL2392187 | — | — | 1 | - |
| CHEMBL2392186 | — | — | 1 | - |
| CHEMBL3290441 | — | — | 1 | - |
| CHEMBL3290185 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128729 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3290186 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL140 | CURCUMIN | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2392188 | — | IC50 | = | 43800.0 | nM | 4.36 |
| CHEMBL3290439 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL318743 | TETRAHYDROCURCUMIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | > | 50000.0 | nM | - |
| CHEMBL2413471 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2392187 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2392186 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3290441 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3290185 | — | IC50 | > | 50000.0 | nM | - |