Assay Detail
Binding
CHEMBL3295183
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Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide as substrate by spectrophotometry
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.19 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137922 | — | — | 1 | 6.22 |
| CHEMBL3289121 | — | — | 1 | 6.16 |
| CHEMBL336718 | — | — | 1 | 5.96 |
| CHEMBL3289115 | — | — | 1 | 5.93 |
| CHEMBL3289116 | — | — | 1 | 5.82 |
| CHEMBL3289123 | — | — | 1 | 5.75 |
| CHEMBL3289122 | — | — | 1 | 5.75 |
| CHEMBL3289384 | — | — | 1 | 5.68 |
| CHEMBL3289117 | — | — | 1 | 5.68 |
| CHEMBL3289112 | — | — | 1 | 5.55 |
| CHEMBL3289119 | — | — | 1 | 5.50 |
| CHEMBL1333995 | — | — | 1 | 5.26 |
| CHEMBL1526444 | — | — | 1 | 5.00 |
| CHEMBL1164165 | — | — | 1 | 4.70 |
| CHEMBL3289108 | — | — | 1 | 4.65 |
| CHEMBL3289120 | — | — | 1 | 4.51 |
| CHEMBL3289113 | — | — | 1 | 4.42 |
| CHEMBL1163173 | — | — | 1 | 4.40 |
| CHEMBL3289124 | — | — | 1 | 4.36 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | — | 1 | 4.34 |
| CHEMBL3289111 | — | — | 1 | 4.30 |
| CHEMBL3289118 | — | — | 1 | 4.21 |
| CHEMBL127066 | — | — | 1 | - |
| CHEMBL3289114 | — | — | 1 | - |
| CHEMBL3289110 | — | — | 1 | - |
| CHEMBL3289109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137922 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3289121 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL336718 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3289115 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL3289116 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3289123 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3289122 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3289384 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3289117 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3289112 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3289119 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1333995 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1526444 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1164165 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL3289108 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL3289120 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL3289113 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL1163173 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL3289124 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | IC50 | = | 45750.0 | nM | 4.34 |
| CHEMBL3289111 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL3289118 | — | IC50 | = | 61030.0 | nM | 4.21 |
| CHEMBL127066 | — | IC50 | = | 177000.0 | nM | - |
| CHEMBL3289114 | — | IC50 | = | 120500.0 | nM | - |
| CHEMBL3289110 | — | IC50 | = | 198200.0 | nM | - |
| CHEMBL3289109 | — | IC50 | = | 172700.0 | nM | - |