Assay Detail
Binding
CHEMBL3295225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat PDE4B
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL3382) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 10.65 | 10.70 |
| pIC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3288029 | — | — | 1 | 10.70 |
| CHEMBL3288030 | — | — | 1 | 10.60 |
| CHEMBL3287739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3288029 | — | IC50 | = | 0.01995 | nM | 10.70 |
| CHEMBL3288030 | — | IC50 | = | 0.02512 | nM | 10.60 |
| CHEMBL3287739 | — | pIC50 | - | — | - |