3',5'-cyclic-AMP phosphodiesterase 4B · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P14646. Use UniProt P14646 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P14646 as the stable identity anchor, then attach disease evidence before program review.
3',5'-cyclic-AMP phosphodiesterase 4B
Review this target as 3',5'-cyclic-AMP phosphodiesterase 4B, mapped to UniProt P14646. Sequence length is 736 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 3',5'-cyclic-AMP phosphodiesterase 4B as ChEMBL target CHEMBL3382, mapped to UniProt P14646. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 3',5'-cyclic-AMP phosphodiesterase 4B is the right protein anchor across sources, using UniProt P14646 as the stable mapping.
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| Preferred Name | 3',5'-cyclic-AMP phosphodiesterase 4B |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P14646 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3',5'-cyclic-AMP phosphodiesterase 4B |
| UniProt Accession | P14646 |
| Component Type | Protein |
| Sequence Length | 736 aa |
3',5'-cyclic-AMP phosphodiesterase 4B
Review this target as 3',5'-cyclic-AMP phosphodiesterase 4B, mapped to UniProt P14646. Sequence length is 736 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3288029 | 10.7 | IC50 | 0.01995 | Preclinical |
| CHEMBL3288030 | 10.6 | IC50 | 0.02512 | Preclinical |
| CHEMBL97817 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL161115 | 7.35 | IC50 | 45.0 | Preclinical |
| CHEMBL74078 | 7.31 | IC50 | 49.0 | Preclinical |
| CHEMBL97214 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL98662 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL351613 | 7.09 | IC50 | 81.0 | Preclinical |
| CHEMBL161740 | 7.07 | IC50 | 85.0 | Preclinical |
| CHEMBL161465 | 6.96 | IC50 | 110.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 20 | 6.6 |
| assay format | 1 | 16 | 6.4 |
| cell-based format | 1 | 0 | — |