Compound Detail
CHEMBL161115
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Basic Information
| ChEMBL ID | CHEMBL161115 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WYEOCWCFOOXSMR-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
360.8
MW (Da)
5.32
ALogP
3
HBA
1
HBD
63.1
PSA (Ų)
0.54
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL3382 | IC50 | 7.35 | 7.35 | 45.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | IC50 | 7.23 | 7.23 | 59.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4C CHEMBL291 | IC50 | 6.72 | 6.72 | 190.0 | 1 |
| Phosphodiesterase 4 CHEMBL2094267 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 2.0 | nM | 8.7 | Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expre... | 10691693 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 45.0 | nM | 7.35 | Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source express... | 10691693 |
| 3',5'-cyclic-AMP phosphodiesterase 4A | IC50 | = | 59.0 | nM | 7.23 | Inhibitory activity against Phosphodiesterase 4A (PDE4A) from human source expre... | 10691693 |
| 3',5'-cyclic-AMP phosphodiesterase 4C | IC50 | = | 190.0 | nM | 6.72 | Inhibitory activity against Phosphodiesterase 4C (PDE4C) from human source expre... | 10691693 |
| Phosphodiesterase 4 | IC50 | = | 800.0 | nM | 6.1 | Inhibition of [3H]rolipram binding to rat brain membranes | 10691693 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10691693 | 10.1021/jm991094u | Rattus norvegicus | 5 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4A | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4C | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 10691693 | 10.1021/jm991094u | Phosphodiesterase 4 | 1 |
| 10691693 | 10.1021/jm991094u | Homo sapiens | 1 |
| 10691693 | 10.1021/jm991094u | Phosphodiesterase 3 | 1 |
| 10691693 | 10.1021/jm991094u | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine