Assay Detail
Binding
CHEMBL761827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expressed in Saccharomyces cerevisiae
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.47 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74078 | — | — | 1 | 9.00 |
| CHEMBL161115 | — | — | 1 | 8.70 |
| CHEMBL161465 | — | — | 1 | 8.70 |
| CHEMBL351613 | — | — | 1 | 8.52 |
| CHEMBL161740 | — | — | 1 | 8.40 |
| CHEMBL351500 | — | — | 1 | 8.15 |
| CHEMBL162188 | — | — | 1 | 8.10 |
| CHEMBL351900 | — | — | 1 | 7.96 |
| CHEMBL161714 | — | — | 1 | 7.32 |
| CHEMBL345360 | — | — | 1 | 7.16 |
| CHEMBL158286 | — | — | 1 | 7.14 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.10 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.41 |
| CHEMBL345812 | — | — | 1 | 5.80 |
| CHEMBL161602 | — | — | 1 | 5.70 |
| CHEMBL351915 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74078 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL161115 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL161465 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL351613 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL161740 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL351500 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL162188 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL351900 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL161714 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL345360 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL158286 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL345812 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL161602 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL351915 | — | IC50 | = | 4100.0 | nM | 5.39 |