Compound Detail
CHEMBL351500
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Basic Information
| ChEMBL ID | CHEMBL351500 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KJLVJCFCBOJYEX-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
291.3
MW (Da)
3.93
ALogP
4
HBA
0
HBD
68.9
PSA (Ų)
0.41
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 8.15 | 8.15 | 7.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL3382 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | IC50 | 6.55 | 6.55 | 279.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4C CHEMBL291 | IC50 | 6.05 | 6.05 | 890.0 | 1 |
| Homo sapiens CHEMBL372 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 7.0 | nM | 8.15 | Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expre... | 10691693 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 150.0 | nM | 6.82 | Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source express... | 10691693 |
| 3',5'-cyclic-AMP phosphodiesterase 4A | IC50 | = | 279.0 | nM | 6.55 | Inhibitory activity against Phosphodiesterase 4A (PDE4A) from human source expre... | 10691693 |
| 3',5'-cyclic-AMP phosphodiesterase 4C | IC50 | = | 890.0 | nM | 6.05 | Inhibitory activity against Phosphodiesterase 4C (PDE4C) from human source expre... | 10691693 |
| Homo sapiens | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of fMLP-induced oxidative burst in human eosinophils | 10691693 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4A | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4C | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 10691693 | 10.1021/jm991094u | Phosphodiesterase 4 | 1 |
| 10691693 | 10.1021/jm991094u | Homo sapiens | 1 |
| 10691693 | 10.1021/jm991094u | Phosphodiesterase 3 | 1 |
| 10691693 | 10.1021/jm991094u | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine