Assay Detail
Functional
CHEMBL822600
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Inhibition of fMLP-induced oxidative burst in human eosinophils
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.29 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74078 | — | — | 1 | 6.16 |
| CHEMBL351613 | — | — | 1 | 5.52 |
| CHEMBL351500 | — | — | 1 | 5.52 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.51 |
| CHEMBL161465 | — | — | 1 | 5.00 |
| CHEMBL162188 | — | — | 1 | 4.96 |
| CHEMBL345360 | — | — | 1 | 4.38 |
| CHEMBL351915 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74078 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL351613 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL351500 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL161465 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL162188 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL345360 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL351915 | — | IC50 | = | 548000.0 | nM | - |