Evidence Snapshot

Homo sapiens

CHEMBL372 ORGANISM Homo sapiens

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:03Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 5:44 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL372

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Homo sapiens as ChEMBL target CHEMBL372. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

Homo sapiens

ORGANISM · Homo sapiens

As of 2026-09-13

ChEMBL target ID

CHEMBL372

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Homo sapiens matters

As of 2026-09-13

Homo sapiens is reviewed as Homo sapiens; the current evidence base includes 58 approved drugs, 11140 compounds, and 12722 assays, with lead potency reaching pChEMBL 11.0.

Protein context

Homo sapiens

Review this target as Homo sapiens.

Protein source · UniProt accession via ChEMBL component mapping

Disease context

Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Activity base

Portfolio and assay base

ChEMBL currently tracks 58 approved drugs, 11140 compounds, and 12722 assays for this target. The dominant activity type is IC50. CHEMBL176441 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL176441 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine

58 approved pChEMBL 11.0

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?

Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Homo sapiens matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

11140

Total Compounds

12722

Total Assays

Approved Drugs

IC50: 6735.0, KI: 22.0, EC50: 709.0, KD: 130.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL176441	11.0	IC50	—
No preferred name CHEMBL1203039	10.9	IC50	—
No preferred name CHEMBL1203038	10.9	IC50	—
No preferred name CHEMBL351742	10.9	IC50	—
No preferred name CHEMBL1203053	10.8	IC50	—

Approved Drugs

Structure	Compound	First Approval
	POMALIDOMIDE CHEMBL43452	2013
	ICATIBANT CHEMBL2028850	2008
	DARUNAVIR CHEMBL1323	2006
	LENALIDOMIDE CHEMBL848	2005
	MYCOPHENOLIC ACID CHEMBL866	2004
	ILOPROST CHEMBL494	2003
	VALDECOXIB CHEMBL865	2001
	RAMATROBAN CHEMBL361812	2000
	SIROLIMUS CHEMBL413	1999
	CELECOXIB CHEMBL118	1998
	TIROFIBAN CHEMBL916	1998
	ZILEUTON CHEMBL93	1996
	ZAFIRLUKAST CHEMBL603	1996
	PRANLUKAST CHEMBL21333	1995
	EPOPROSTENOL CHEMBL1139	1995
	TACROLIMUS ANHYDROUS CHEMBL269732	1994
	TRIMETREXATE CHEMBL119	1993
	CALCIPOTRIENE CHEMBL1200666	1993
	TOLRESTAT CHEMBL436	1989
	CLOZAPINE CHEMBL42	1989
	GANCICLOVIR CHEMBL182	1989
	ZIDOVUDINE CHEMBL129	1987
	MILRINONE CHEMBL189	1987
	MITOXANTRONE CHEMBL58	1987
	ETOPOSIDE CHEMBL44657	1983
	CYCLOSPORINE CHEMBL160	1983
	ACYCLOVIR CHEMBL184	1982
	MITOMYCIN CHEMBL105	1981
	ALPROSTADIL CHEMBL495	1981
	KETOCONAZOLE CHEMBL157101	1981
	CALCITRIOL CHEMBL846	1978
	DOXORUBICIN CHEMBL53463	1974
	INDOMETHACIN CHEMBL6	1965
	DACTINOMYCIN CHEMBL1554	1964
	METHOTREXATE CHEMBL34259	1953

← Target Page

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:03Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 5:44 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL372