Assay Detail
Binding
CHEMBL765475
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Inhibitory activity against Phosphodiesterase 4A (PDE4A) from human source expressed in Saccharomyces cerevisiae
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.27 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL161115 | — | — | 1 | 7.23 |
| CHEMBL74078 | — | — | 1 | 7.06 |
| CHEMBL351613 | — | — | 1 | 6.92 |
| CHEMBL161740 | — | — | 1 | 6.85 |
| CHEMBL351500 | — | — | 1 | 6.55 |
| CHEMBL161465 | — | — | 1 | 6.46 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.39 |
| CHEMBL158286 | — | — | 1 | 6.11 |
| CHEMBL161714 | — | — | 1 | 5.85 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.85 |
| CHEMBL351900 | — | — | 1 | 5.75 |
| CHEMBL345360 | — | — | 1 | 5.42 |
| CHEMBL162188 | — | — | 1 | 5.02 |
| CHEMBL351915 | — | — | 1 | - |
| CHEMBL345812 | — | — | 1 | - |
| CHEMBL161602 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL161115 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL74078 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL351613 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL161740 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL351500 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL161465 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL158286 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL161714 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL351900 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL345360 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL162188 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL351915 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL345812 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL161602 | — | IC50 | > | 10000.0 | nM | - |