Compound Detail
CHEMBL345812
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Basic Information
| ChEMBL ID | CHEMBL345812 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QEROEWFWSVQFIF-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
266.3
MW (Da)
2.79
ALogP
5
HBA
1
HBD
94.9
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL3382 | IC50 | 5.34 | 5.34 | 4600.0 | 1 |
| Phosphodiesterase 4 CHEMBL2094267 | IC50 | 4.39 | 4.39 | 41000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 1600.0 | nM | 5.8 | Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expre... | 10691693 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 4600.0 | nM | 5.34 | Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source express... | 10691693 |
| Phosphodiesterase 4 | IC50 | = | 41000.0 | nM | 4.39 | Inhibition of [3H]rolipram binding to rat brain membranes | 10691693 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4A | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4C | 1 |
| 10691693 | 10.1021/jm991094u | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 10691693 | 10.1021/jm991094u | Phosphodiesterase 4 | 1 |
| 10691693 | 10.1021/jm991094u | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine