Assay Detail
Functional
CHEMBL3295322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 Ba-L subtype B infected in human PBMC assessed as reverse transcriptase activity after 6 days by microtiter plate-based assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationship studies of indole-based compounds as small molecule HIV-1 fusion inhibitors targeting glycoprotein 41.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC90 | 3 | - | - |
| EC50 | 3 | 6.98 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 2 | 8.12 |
| CHEMBL3290362 | — | — | 2 | 6.44 |
| CHEMBL3290363 | — | — | 2 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525076 | ENFUVIRTIDE | EC50 | = | 7.55 | nM | 8.12 |
| CHEMBL3290362 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3290363 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3290362 | — | EC90 | = | 630.0 | nM | - |
| CHEMBL3290363 | — | EC90 | = | 590.0 | nM | - |
| CHEMBL525076 | ENFUVIRTIDE | EC90 | = | 23.6 | nM | - |