Assay Detail
Functional
CHEMBL3296130
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Antiplasmodial activity against Plasmodium falciparum Dd2 harboring DHODH mutant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.59 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.74 |
| CHEMBL1706506 | — | — | 1 | 7.77 |
| CHEMBL3289810 | — | — | 1 | 7.71 |
| CHEMBL2012958 | — | — | 1 | 7.12 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 1.81 | nM | 8.74 |
| CHEMBL1706506 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL3289810 | — | IC50 | = | 19.72 | nM | 7.71 |
| CHEMBL2012958 | — | IC50 | = | 76.8 | nM | 7.12 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 257.0 | nM | 6.59 |