Assay Detail

CHEMBL3296133

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Functional

Antiplasmodial activity against Plasmodium falciparum Dd2 harboring CYTb-Qi mutant

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.

Hameed P S, Chinnapattu M, Shanbag G, Manjrekar P, Koushik K, Raichurkar A, Patil V, Jatheendranath S, Rudrapatna SS, Barde SP, Rautela N, Awasthy D, Morayya S, Narayan C, Kavanagh S, Saralaya R, Bharath S, Viswanath P, Mukherjee K, Bandodkar B, Srivastava A, Panduga V, Reddy J, Prabhakar KR, Sinha A, Jiménez-Díaz MB, Martínez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Magistrado PA, Lukens AK, Wirth DF, Waterson D, Balasubramanian V, Iyer PS, Narayanan S, Hosagrahara V, Sambandamurthy VK, Ramachandran S.
J Med Chem (2014) 57 : 5702 -5713
PubMed 24914738 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	5	8.02	8.90

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL269671	ARTEMISININ	3.0	1	8.90
CHEMBL1706506	—	—	1	8.50
CHEMBL2012958	—	—	1	8.00
CHEMBL3289810	—	—	1	7.93
CHEMBL278315	GELDANAMYCIN	2.0	1	6.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL269671	ARTEMISININ	IC50	=	1.26	nM	8.90
CHEMBL1706506	—	IC50	=	3.16	nM	8.50
CHEMBL2012958	—	IC50	=	9.94	nM	8.00
CHEMBL3289810	—	IC50	=	11.79	nM	7.93
CHEMBL278315	GELDANAMYCIN	IC50	=	169.0	nM	6.77