Assay Detail
Binding
CHEMBL3296176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TrxR activity in human HeLa cell lysate after 12 hrs by insulin reduction assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.63 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290761 | — | — | 1 | 5.85 |
| CHEMBL3290759 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290761 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3290759 | — | IC50 | = | 4000.0 | nM | 5.40 |