Assay Detail
Binding
CHEMBL3296351
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rat DHODH by isothermal titration calorimetry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL2383) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.32 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289671 | — | — | 1 | 7.32 |
| CHEMBL1738786 | — | — | 1 | - |
| CHEMBL492529 | — | — | 1 | - |
| CHEMBL3289670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289671 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL1738786 | — | Kd | - | — | - | |
| CHEMBL492529 | — | Kd | - | — | - | |
| CHEMBL3289670 | — | Kd | - | — | - |