Assay Detail
Binding
CHEMBL3296477
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Displacement of [3H]PK11195 from TSPO in rat C6 cell membrane after 90 mins by radioligand binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.27 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | — | 1 | 9.40 |
| CHEMBL339816 | — | — | 1 | 8.80 |
| CHEMBL3287610 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL339816 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3287610 | — | Ki | = | 239.0 | nM | 6.62 |