Assay Detail
Binding
CHEMBL3296715
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AGR quorum sensing system in methicillin-resistant Staphylococcus aureus AH2759 incubated for 15 hrs by P3-LUX reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Accessory gene regulator protein A (CHEMBL1681616) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.06 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289785 | — | — | 1 | 7.92 |
| CHEMBL290932 | — | — | 1 | 5.09 |
| CHEMBL3289786 | — | — | 1 | 5.05 |
| CHEMBL289277 | EMODIN | — | 1 | 4.77 |
| CHEMBL3289787 | — | — | 1 | 4.70 |
| CHEMBL3289788 | — | — | 1 | 4.58 |
| CHEMBL3289789 | — | — | 1 | 4.52 |
| CHEMBL290914 | EMODIC ACID | — | 1 | 4.51 |
| CHEMBL1089732 | — | — | 1 | 4.42 |
| CHEMBL3289790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289785 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL290932 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3289786 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL289277 | EMODIN | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL3289787 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3289788 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL3289789 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL290914 | EMODIC ACID | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL1089732 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL3289790 | — | IC50 | = | 120000.0 | nM | - |