Assay Detail
Binding
CHEMBL3299202
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Inhibition of JAK3 (unknown origin)
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.70 | 7.26 |
| Ki | 1 | 8.60 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3039513 | DECERNOTINIB | 2.0 | 2 | 8.60 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.26 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 6.31 |
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 6.10 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3039513 | DECERNOTINIB | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3039513 | DECERNOTINIB | IC50 | = | 74.4 | nM | 7.13 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL2105759 | BARICITINIB | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL3301607 | FILGOTINIB | IC50 | > | 10000.0 | nM | - |