Assay Detail
Functional
CHEMBL3300531
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human CNE cells after 48 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CNE |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activities of novel α-aminophosphonate derivatives containing an alizarin moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 4.42 | 4.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298491 | — | — | 1 | 4.65 |
| CHEMBL3299072 | — | — | 1 | 4.52 |
| CHEMBL3299064 | — | — | 1 | 4.52 |
| CHEMBL3299066 | — | — | 1 | 4.46 |
| CHEMBL3299061 | — | — | 1 | 4.37 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.35 |
| CHEMBL3298492 | — | — | 1 | 4.33 |
| CHEMBL3299071 | — | — | 1 | 4.31 |
| CHEMBL3298494 | — | — | 1 | 4.31 |
| CHEMBL3298489 | — | — | 1 | - |
| CHEMBL3298488 | — | — | 1 | - |
| CHEMBL3298487 | — | — | 1 | - |
| CHEMBL3298486 | — | — | 1 | - |
| CHEMBL3298485 | — | — | 1 | - |
| CHEMBL3298484 | — | — | 1 | - |
| CHEMBL3298396 | — | — | 1 | - |
| CHEMBL3298395 | — | — | 1 | - |
| CHEMBL3298394 | — | — | 1 | - |
| CHEMBL3298393 | — | — | 1 | - |
| CHEMBL3298490 | — | — | 1 | - |
| CHEMBL3298493 | — | — | 1 | - |
| CHEMBL3299062 | — | — | 1 | - |
| CHEMBL55814 | ATHRAQUINONES A | — | 1 | - |
| CHEMBL3299063 | — | — | 1 | - |
| CHEMBL3298558 | — | — | 1 | - |
| CHEMBL3299065 | — | — | 1 | - |
| CHEMBL3299070 | — | — | 1 | - |
| CHEMBL3299067 | — | — | 1 | - |
| CHEMBL3299068 | — | — | 1 | - |
| CHEMBL3299069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298491 | — | IC50 | = | 22190.0 | nM | 4.65 |
| CHEMBL3299072 | — | IC50 | = | 30480.0 | nM | 4.52 |
| CHEMBL3299064 | — | IC50 | = | 30160.0 | nM | 4.52 |
| CHEMBL3299066 | — | IC50 | = | 34250.0 | nM | 4.46 |
| CHEMBL3299061 | — | IC50 | = | 43060.0 | nM | 4.37 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL3298492 | — | IC50 | = | 47280.0 | nM | 4.33 |
| CHEMBL3299071 | — | IC50 | = | 49410.0 | nM | 4.31 |
| CHEMBL3298494 | — | IC50 | = | 48710.0 | nM | 4.31 |
| CHEMBL3298489 | — | IC50 | - | — | - | |
| CHEMBL3298488 | — | IC50 | - | — | - | |
| CHEMBL3298487 | — | IC50 | - | — | - | |
| CHEMBL3298486 | — | IC50 | - | — | - | |
| CHEMBL3298485 | — | IC50 | - | — | - | |
| CHEMBL3298484 | — | IC50 | - | — | - | |
| CHEMBL3298396 | — | IC50 | - | — | - | |
| CHEMBL3298395 | — | IC50 | - | — | - | |
| CHEMBL3298394 | — | IC50 | - | — | - | |
| CHEMBL3298393 | — | IC50 | - | — | - | |
| CHEMBL3298490 | — | IC50 | - | — | - | |
| CHEMBL3298493 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3299062 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL55814 | ATHRAQUINONES A | IC50 | > | 100000.0 | nM | - |
| CHEMBL3299063 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3298558 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3299065 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3299070 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3299067 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3299068 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3299069 | — | IC50 | > | 50000.0 | nM | - |