Assay Detail
Functional
CHEMBL3300993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against zidovudine-resistant HIV1 harboring RT 67N, 70R, 215F, 219Q mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity after 4 days by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of novel fluoro analogues of MKC442 as microbicides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.50 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 9.00 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 9.00 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.70 |
| CHEMBL240386 | — | — | 1 | 8.40 |
| CHEMBL3298051 | — | — | 1 | 8.00 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 8.00 |
| CHEMBL3297960 | — | — | 1 | 7.40 |
| CHEMBL3297961 | — | — | 1 | 7.30 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.22 |
| CHEMBL3298048 | — | — | 1 | 7.16 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 7.10 |
| CHEMBL3298130 | — | — | 1 | 7.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.70 |
| CHEMBL3298049 | — | — | 1 | 6.52 |
| CHEMBL3298050 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL240386 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3298051 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3297960 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3297961 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3298048 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL35033 | EMIVIRINE | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3298130 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3298049 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3298050 | — | EC50 | = | 11000.0 | nM | 4.96 |