Assay Detail
Functional
CHEMBL3361805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against C3H/HeN mouse abdominal cavity cells assessed as inhibition of LPS-induced PGE2 production after 6 hrs by EIA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Abdominal cavity |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.25 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3326970 | — | — | 1 | 7.00 |
| CHEMBL3327091 | — | — | 1 | 6.75 |
| CHEMBL3326971 | — | — | 1 | 6.68 |
| CHEMBL3327095 | — | — | 1 | 6.55 |
| CHEMBL3327092 | — | — | 1 | 6.30 |
| CHEMBL3326969 | — | — | 1 | 6.28 |
| CHEMBL3326966 | — | — | 1 | 6.27 |
| CHEMBL3327094 | — | — | 1 | 6.15 |
| CHEMBL3327089 | — | — | 1 | 6.10 |
| CHEMBL3327090 | — | — | 1 | 6.07 |
| CHEMBL3327093 | — | — | 1 | 6.07 |
| CHEMBL3327088 | — | — | 1 | 6.05 |
| CHEMBL3326968 | — | — | 1 | 5.92 |
| CHEMBL3326948 | — | — | 1 | 5.89 |
| CHEMBL3326967 | — | — | 1 | 5.64 |
| CHEMBL221504 | — | — | 1 | - |
| CHEMBL272342 | EFIPLADIB | 2.0 | 1 | - |
| CHEMBL3326965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3326970 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3327091 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3326971 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3327095 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3327092 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3326969 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3326966 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3327094 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3327089 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3327090 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3327093 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3327088 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3326968 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3326948 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3326967 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL221504 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL272342 | EFIPLADIB | IC50 | < | 100.0 | nM | - |
| CHEMBL3326965 | — | IC50 | - | — | - |