Assay Detail
Binding
CHEMBL3362240
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Inhibition of human PDE4D
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of triazines as selective PDE4B versus PDE4D inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.40 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3313945 | — | — | 1 | 8.15 |
| CHEMBL3315271 | — | — | 1 | 7.89 |
| CHEMBL3315265 | — | — | 1 | 7.70 |
| CHEMBL3315273 | — | — | 1 | 7.20 |
| CHEMBL3315275 | — | — | 1 | 7.02 |
| CHEMBL3315272 | — | — | 1 | 6.88 |
| CHEMBL3315274 | — | — | 1 | 6.80 |
| CHEMBL3315262 | — | — | 1 | 6.68 |
| CHEMBL3315270 | — | — | 1 | 6.67 |
| CHEMBL3315263 | — | — | 1 | 6.66 |
| CHEMBL3315261 | — | — | 1 | 6.60 |
| CHEMBL3315267 | — | — | 1 | 6.57 |
| CHEMBL3315266 | — | — | 1 | 6.57 |
| CHEMBL3315276 | — | — | 1 | 6.22 |
| CHEMBL3315269 | — | — | 1 | 6.17 |
| CHEMBL3315258 | — | — | 1 | 6.14 |
| CHEMBL3315255 | — | — | 1 | 6.14 |
| CHEMBL3315257 | — | — | 1 | 6.07 |
| CHEMBL3315248 | — | — | 1 | 6.06 |
| CHEMBL3315264 | — | — | 1 | 6.05 |
| CHEMBL3315251 | — | — | 1 | 5.93 |
| CHEMBL3315250 | — | — | 1 | 5.83 |
| CHEMBL3315254 | — | — | 1 | 5.68 |
| CHEMBL3315259 | — | — | 1 | 5.64 |
| CHEMBL3315247 | — | — | 1 | 5.45 |
| CHEMBL3315252 | — | — | 1 | 5.25 |
| CHEMBL3315253 | — | — | 1 | 4.65 |
| CHEMBL3315268 | — | — | 1 | - |
| CHEMBL3315256 | — | — | 1 | - |
| CHEMBL3315249 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3313945 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3315271 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3315265 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3315273 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3315275 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3315272 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL3315274 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3315262 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL3315270 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL3315263 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL3315261 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL3315267 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL3315266 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL3315276 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3315269 | — | IC50 | = | 681.0 | nM | 6.17 |
| CHEMBL3315255 | — | IC50 | = | 727.0 | nM | 6.14 |
| CHEMBL3315258 | — | IC50 | = | 726.0 | nM | 6.14 |
| CHEMBL3315257 | — | IC50 | = | 859.0 | nM | 6.07 |
| CHEMBL3315248 | — | IC50 | = | 865.0 | nM | 6.06 |
| CHEMBL3315264 | — | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL3315251 | — | IC50 | = | 1181.0 | nM | 5.93 |
| CHEMBL3315250 | — | IC50 | = | 1489.0 | nM | 5.83 |
| CHEMBL3315254 | — | IC50 | = | 2107.0 | nM | 5.68 |
| CHEMBL3315259 | — | IC50 | = | 2268.0 | nM | 5.64 |
| CHEMBL3315247 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL3315252 | — | IC50 | = | 5611.0 | nM | 5.25 |
| CHEMBL3315253 | — | IC50 | = | 22260.0 | nM | 4.65 |
| CHEMBL3315268 | — | IC50 | - | — | - | |
| CHEMBL3315256 | — | IC50 | - | — | - | |
| CHEMBL3315249 | — | IC50 | - | — | - | |
| CHEMBL3315260 | — | IC50 | - | — | - | |
| CHEMBL3315246 | — | IC50 | - | — | - |