Compound Detail
CHEMBL3315275
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Basic Information
| ChEMBL ID | CHEMBL3315275 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OFISQNBGNCPVKB-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
382.9
MW (Da)
4.69
ALogP
5
HBA
2
HBD
88.0
PSA (Ų)
0.64
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 7.02 | 7.02 | 96.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.02 | 7.02 | 96.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 5.96 | 5.96 | 1090.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 96.0 | nM | 7.02 | Inhibition of human PDE4D | 24998378 |
| Unchecked | IC50 | = | 96.0 | nM | 7.02 | Inhibition of recombinant human His6-tagged PDE4D7 UCR1 S129D mutant expressed i... | 31013090 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 1090.0 | nM | 5.96 | Inhibition of human PDE4B | 24998378 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 1090.0 | nM | 5.96 | Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed i... | 31013090 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31013090 | 10.1021/acs.jmedchem.9b00193 | Unchecked | 3 |
| 24998378 | 10.1016/j.bmcl.2014.06.002 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 24998378 | 10.1016/j.bmcl.2014.06.002 | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 24998378 | 10.1016/j.bmcl.2014.06.002 | Unchecked | 1 |
| 31013090 | 10.1021/acs.jmedchem.9b00193 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
Data from ChEMBL 36 via Core Engine